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Learn more about your fertility journey.
Crinone  Important Safety Information
Crinone  Prescribing Information
A Daily Dose to Support Your Dream
Dear [~firstname~] [~lastname~],

If you've had a chance to talk to a specialist about your fertility treatment options, you're probably aware of the important role progesterone plays in helping the body achieve and maintain a pregnancy.
Learn More About
How Your Body Prepares for Pregnancy
Learn More About How Your Body Prepares for Pregnancy

CRINONE 8% (progesterone gel) is indicated for progesterone supplementation or replacement as part of an Assisted Reproductive Technology (ART) treatment for infertile women with progesterone deficiency.

See Important Risk Information below.

Certain medications and techniques used in assisted reproductive technology (ART), including IVF, can interfere with natural progesterone production by the body. Because of this, your doctor might need to supplement or replace progesterone to ensure the embryo is supported.
Learn More About
The Need for Progesterone
Learn More About The Need for Progesterone DURING ART TREATMENT
CRINONE is Preferred and Proven
When your doctor recommends the use of progesterone, know that you have a choice. Ask for once-daily CRINONE.
CRINONE is Preferred and Proven
Survey results showed that women trying to conceive preferred progesterone gel compared to vaginal capsules or injectable options1, 2
The #1 prescribed vaginal progesterone as part of assisted reproductive technology treatment3
Covered by many of the top commercial plans4
at CrinoneUSA.com

You should not use CRINONE 8% (progesterone gel) if you have any disorders involving blockage of your blood vessels, or a history of these disorders, miscarriages, vaginal bleeding that hasn't been diagnosed, liver problems or disease, or known or possible cancer of the breast or genital organs.

You should discontinue use of CRINONE 8% if any symptoms occur that signal a blockage of your blood vessels. There is no evidence that CRINONE 8% will work in preventing miscarriage. Your doctor should examine your breasts and pelvic organs, as well as perform a Pap smear prior to prescribing CRINONE 8%. If you have vaginal bleeding during treatment with CRINONE 8%, your doctor should look for the cause. If you have conditions that cause fluid retention, a history of depression, or diabetes, your doctor should provide special attention to your care while you are using CRINONE 8%.

The most common side effects of CRINONE 8% include breast enlargement, constipation, drowsiness, nausea, headache, and pain in the pubic area.

Please also see full Patient Information.

References: 1. Yanushpolsky E, Hurwitz S, Greenberg L, et al. Crinone vaginal gel is equally effective and better tolerated than intramuscular progesterone for luteal phase support in in vitro fertilization – embryo transfer cycles: a prospective randomized study. Fertil Steril. 2010;94(7):2596-9. 2. Simunic V, Tomic V, Tomic J, Nizic D. Comparative study of the efficacy and tolerability of two vaginal progesterone formulations, Crinone 8% gel and Utrogestan capsules, used for luteal support. Fertil Steril. 2007;87(1):83-7 3. IMS Health National Prescription Audit and Xponent Report. December 2013. Actavis, Inc. 4. Fingertip Formulary accessed 6/15/15.
CRINONE® is a registered trademark of Actavis, Inc.
© 2015 Actavis. All rights reserved. CRI31383 07/15